Computational Biologist I

About this role

About the Job The Computational Biologist I contributes to the early innovation of novel bioinformatics methods and genomic signatures in oncology. Leveraging Foundation Medicine’s FoundationCORE dataset of 800,000+ samples and the Flatiron Health-Foundation Medicine joint Clinico-Genomic Database of 100,000+ samples with annotated clinical outcomes, this role explores novel patterns in cancer biology. The position plays a key role in conducting original research, generating insights, and preparing high-impact scientific abstracts, presentations, and peer-reviewed manuscripts

The work drives foundational understanding that supports clinical diagnostics and translational research in oncology. In addition to research, this role develops sub-specialization in the data architecture supporting the team’s efforts, including pipeline workflow development, cloud-based data storage, and maintaining data quality and integrity. Key Responsibilities Develop and evaluate potential signatures and biomarkers using large-scale datasets; investigate genomic mechanisms underlying oncogenesis

Apply statistical analyses, analyze genomic data via HPC clusters, and improve assay performance. Organize, visualize, and interpret data in a high-throughput, data-intensive environment. Collaborate with internal cross-functional teams — including R&D, Medical, Commercial, Biopharma, and Regulatory — and engage with external collaborators to support enterprise goals

Work closely with molecular biologists, computational scientists, and regulatory teams to inform the feasibility and planning of translational next-generation sequencing (NGS) assays. Maintain awareness of current bioinformatics methods and diagnostic oncology literature. Prepare and present results in internal meetings and contribute to scientific literature

Design and refine bioinformatics algorithms, workflows, and analysis pipelines; manage cloud-based data infrastructure and ensure data quality. Build, maintain, and enhance

Apply for this role on Foundation Medicine’s official careers site.